physical carcinogens ppt

12 Dec physical carcinogens ppt

0000112477 00000 n ���ˡcJj�'D\��Vub�N����Sz��F楶���TP�#M�9�R��y�����#�(�UYs�ơ�>� "�а7sZУ�u 1J�� g�9�.b�ҩ��pj�6��Ր��o��c�%���O�{{�n5(c���n�������� �{x/�x�b�lW8F#Msb��)�~���!#��I�8��n3�/Xd7 �y���nQѝ�3b[���uV�>��p�(1[��F��YgTwE� k�3�X1#��g��>�����-yj�")�Izz^B_�M���ʛ^ia�92lV��֏� �-ˈ���x����/�x@���5�E��_���o��s}/���>��f����ױG���X��o��F?�o fore, the mutational spectra of chemical and physical carcinogens in these critical genes are of interest to define endogenous and exogenous muta tional mechanisms. 0000100803 00000 n 0000103589 00000 n 0000108762 00000 n 0000095484 00000 n 0000059018 00000 n 0000060418 00000 n 0000099066 00000 n In industry, there are many potential exposures to carcinogens. 0000103491 00000 n 0000096701 00000 n 0000066568 00000 n 0000111111 00000 n 0000108159 00000 n Right to know. 0000080666 00000 n 0000081545 00000 n 0000103839 00000 n 0000101169 00000 n <]>> 0000066813 00000 n 0000051703 00000 n 0000085088 00000 n Get the plugin now. 0000085547 00000 n 0000086237 00000 n 0000080617 00000 n Examples of ionising radiation include X-rays and alpha, beta and gamma radiation. 0000090314 00000 n 0000111552 00000 n 0000091010 00000 n 0000091664 00000 n 0000081164 00000 n 0000105084 00000 n Lung (2.09 million cases) 2. 0000075582 00000 n 0000068629 00000 n 0000068992 00000 n 0000106781 00000 n 0000099173 00000 n 0000017435 00000 n 0000080862 00000 n 0000061987 00000 n 0000065896 00000 n 0000075095 00000 n 0000103060 00000 n 0000109723 00000 n høt¡ â _rels/.rels ¢(  ¬’ÛJ1†ïß!Ì}7Û*"ÒloDèÈú c2»ÝH¦Ò¾½¡àaa-‚½œÓ?_òÏz³w£x§”mð 0000108110 00000 n ©=ªWí\ßáÉksd÷£D&gúvû÷&Ýý ÿÿ PK ! 0000058932 00000 n Upper/lower flammability or explosive limits . PPT-107-01. 0000064568 00000 n 0000020904 00000 n 4. 0000104271 00000 n 0000070387 00000 n 0000081749 00000 n 0000098854 00000 n Such an analysis has revealed evidence for both exogenous and endogenous molecular mechanisms of Colorectal (1.80 million cases) 4. 0000064108 00000 n 0000075636 00000 n 0000101987 00000 n 0000069613 00000 n 0000081896 00000 n Generally, workplace exposures are considered to be at higher levels than for public exposures. 0000094350 00000 n 0000085444 00000 n 0000066405 00000 n 0000077812 00000 n 0000089192 00000 n 0000085650 00000 n 0000066666 00000 n 0000100646 00000 n 0000096511 00000 n 0000112526 00000 n menarche Reproductive. 0000092996 00000 n 0000109935 00000 n 0000111062 00000 n Like fibers, particulate matter is most often inhaled, but can also be ingeste… metabolism of benzene in bone marrow 0000066764 00000 n 0000075180 00000 n 0000083362 00000 n 0000095337 00000 n 0000098102 00000 n 0000092515 00000 n 0000097353 00000 n A mutagen is not the same as a carcinogen. 0000066862 00000 n 0000078212 00000 n Multistep model of carcinogenesis. 0000093317 00000 n 0000096560 00000 n 0000101933 00000 n 0000092363 00000 n 0000089602 00000 n 0000082249 00000 n 0000071025 00000 n The Ames test is a widely used test to screen chemicals used in foods or medications for mutagenic potential. 0000070882 00000 n 0000062452 00000 n 0000108056 00000 n 0000065842 00000 n 0000060704 00000 n Particulate matter includes a variety of different compounds that are naturally present as tiny particles. 0000075786 00000 n 0000076927 00000 n Duration of exposure. The process of carcinogenesis may be divided into at least three stages: initiation, promotion, and progression. 0000059894 00000 n 0000108605 00000 n 0000016483 00000 n 0000066960 00000 n Concentration of the toxin. 0000102602 00000 n 0000098628 00000 n That you have done enough. 0000081994 00000 n The word is a general term for a group of diseases that can affect all parts of the body. 0000073763 00000 n 0000029371 00000 n 0000081646 00000 n 0000085856 00000 n 0000084282 00000 n 0000099472 00000 n 0000095533 00000 n PAHs, aflatoxin, vinyl chloride, PhIPs, NNK many more Other enzyme systems can also be important: e.g. 0000083274 00000 n 0000094217 00000 n 0000109777 00000 n 5. 0000017213 00000 n 0000060182 00000 n 0000107733 00000 n 0000023466 00000 n Breast (2.09 million cases) 3. 0000094000 00000 n – 2. 0000070284 00000 n 0000108811 00000 n 0000105808 00000 n 0000095386 00000 n UV radiation can be divided into a number of bands such as UV-B, UV-C … 0000079888 00000 n 0000088875 00000 n 0000096988 00000 n 0000065529 00000 n Some of the chemical mutagens and mutagenesis are given in Table 9.3, and described below: i. 0000071657 00000 n 0000105906 00000 n 0000086768 00000 n 0000060127 00000 n 0000098482 00000 n 0000107080 00000 n 0000070161 00000 n 0000074040 00000 n 0000099566 00000 n 0000067161 00000 n 0000087348 00000 n 0000102504 00000 n 0000073812 00000 n 0000108963 00000 n 0000109066 00000 n 0000081324 00000 n 0000103687 00000 n 0000097662 00000 n 0000068938 00000 n 0000082747 00000 n 0000093158 00000 n 0000080104 00000 n PPT-016-03 16 Effective Completion Date Requirements Who June 1, 2016 Update alternative workplace labeling Employers and hazard communication program as necessary, and provide additional employee training for newly-identified physical or health hazards Transition period May comply with either 29 CFR 1910.1200 Chemical Geeta Mohan Cancer Biology The word ‘cancer’ is derived from the word, ‘carcinos’ the Latin word for crab. 0000069101 00000 n 0000065430 00000 n 0000086536 00000 n 0000086665 00000 n 0000088398 00000 n 0000110284 00000 n 0000096072 00000 n 0000061028 00000 n 0000102097 00000 n 0000101556 00000 n Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division.Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. 0000110964 00000 n 0000020981 00000 n 0000066911 00000 n 3 Ionizing or ultraviolet radiation and most chemical carcinogens cause3. 89 782 0000103226 00000 n 0000100397 00000 n 0000084574 00000 n Presentation Summary : CHEMICAL CARCINOGENS What is a carcinogen? 0000104795 00000 n 0000094539 00000 n 0000058466 00000 n 0000107232 00000 n 0000066230 00000 n 0000077146 00000 n 0000083789 00000 n 0000060758 00000 n 0000100749 00000 n 0000071844 00000 n 0000108257 00000 n 0000085601 00000 n Stomach (1.03 million cases) 1. 0000102450 00000 n 0000067429 00000 n 0000066351 00000 n ISSN: 1831-9343 Exposure to carcinogens and work-related cancer: A review of assessment methods European Risk Observatory Report European Agency for Safety and Health at Work 0000078717 00000 n 0000086866 00000 n 0000058175 00000 n 0000062175 00000 n In 1914, the somatic mutation theory for cancer was put forward. 0000078511 00000 n 0000077499 00000 n 0000082995 00000 n 0000105759 00000 n 0000096224 00000 n 0000089037 00000 n 0000073915 00000 n 0000058349 00000 n 0000095974 00000 n 0000086188 00000 n 0000107946 00000 n 0000063322 00000 n 0000062585 00000 n 0000104018 00000 n 0000072003 00000 n 0000096408 00000 n 0000084726 00000 n 0000077660 00000 n breast disease Age at. Do you have PowerPoint slides to share? 0000017102 00000 n 0000079736 00000 n 0000100110 00000 n 0000020449 00000 n 0000090860 00000 n 0000061504 00000 n 0000076873 00000 n 0000073619 00000 n 0000092417 00000 n 0000092671 00000 n 0000091210 00000 n 0000103388 00000 n 0000085802 00000 n 0000073169 00000 n 0000076336 00000 n 0000092162 00000 n 0000087061 00000 n 0000108355 00000 n 0000091460 00000 n 0000084775 00000 n 0000104968 00000 n 0000079839 00000 n Non-radiation physical agents are the various forms of injury and are less important. 0000112008 00000 n 0000070779 00000 n 0000108914 00000 n 0000083962 00000 n 0000099321 00000 n 0000082146 00000 n 0000067107 00000 n 0000094054 00000 n Routes of entry. 0000111856 00000 n 0000082941 00000 n 0000111013 00000 n 0000063230 00000 n 0000111307 00000 n 0000104914 00000 n 0000080050 00000 n 0000068793 00000 n “Mutagen is a physical, chemical or biological agent that causes mutation by altering the genetic material which possibly results in the disease condition.” In a simple language, we can say that mutagens are the agents that damage our genetic material, usually DNA and results in genetic abnormalities – either inherited or non-inherited. 0000107615 00000 n 0000100501 00000 n 0000084520 00000 n 0000088226 00000 n 0000090084 00000 n 0000101713 00000 n Stress will increase the respiratory and heart . 0000103540 00000 n ... Mutation and cancer - Carcinogens = Mutagens. 0000112325 00000 n H��VM��6���w��X#��1�l9%UT尛����@,;��' c�T�ag���{��[������)��Ҧ��ë�Nkh_�O�4�I�Ɂ5������tI҆T�W NI��:>�Κ'����셏����茲�N����2��|��B��]����6�n���J=">7���H,Ki�`c=Mڈ����'��FF_#" 0000082352 00000 n 0000018579 00000 n Internal and external factors regulate cell division. 0000065583 00000 n 0 0000020727 00000 n 0000089246 00000 n Vapor pressure . 0000065251 00000 n 0000106835 00000 n 0000073269 00000 n 3. 0000059544 00000 n 0000097299 00000 n 0000067893 00000 n 0000081068 00000 n 0000083416 00000 n 0000104619 00000 n 0000100252 00000 n 0000074094 00000 n 0000063737 00000 n Growth factors are proteins that stimulate cell division. 0000078413 00000 n {$��W:��[u�r����h��{b����2��L_�W�?�4dztn�Ʒ�6E��=0�{�כ��T�p=�Ў�k@*�4�=��d�ä��qkhhhDGGG�k@.��dRRB� 0000111356 00000 n 0000103442 00000 n 0000075491 00000 n 0000064839 00000 n 0000070107 00000 n 0000061639 00000 n startxref 0000102656 00000 n 0000089359 00000 n 0000073369 00000 n 0000068847 00000 n 0000108659 00000 n 0000084623 00000 n 0000093726 00000 n 0000089935 00000 n 0000105955 00000 n 0000089722 00000 n 0000078315 00000 n 0000080715 00000 n 0000091110 00000 n 0000087654 00000 n 0000081218 00000 n 0000000016 00000 n 0000086384 00000 n 0000090260 00000 n 0000058741 00000 n 0000077553 00000 n 0000092265 00000 n 0000019615 00000 n endogenous/exogenous exposure to carcinogens Relevant alterations: Genetic (mutation) and epigenetic alteration of target genes in target cells. 0000090632 00000 n 0000078462 00000 n 0000068580 00000 n 0000092857 00000 n 0000074349 00000 n 0000064375 00000 n 0000025906 00000 n 0000091796 00000 n 0000076069 00000 n 0000059417 00000 n If so, share your PPT presentation slides online with PowerShow.com. 0000091410 00000 n This appears to be true whether the active agent is a chemical or ionizing radiation, or if the cancer has a viral etiology. Environmental Sanitation In Community Health Nursing Ppt Assessment Data Goals & Outcome #Community Health Nursing Care Plan #Trailer Statement #1 Statement #2 Resources Ackley, B. 0000070931 00000 n 0000076480 00000 n Prostate (1.28 million cases) 5. 0000105659 00000 n 0000072740 00000 n 0000091260 00000 n 0000078073 00000 n 0000079942 00000 n 0000071199 00000 n 0000017813 00000 n 0000095057 00000 n External factors include physical and chemical signals. chemical carcinogenesis (chemical carcinogens—benzpyrene, asbestos and over 800 chemicals) physical carci-nogenesis (physical carcinogens—ionizing radiation, ultraviolet radiation, etc. 0000076734 00000 n 0000104565 00000 n 0000088344 00000 n 0000105463 00000 n 0000067009 00000 n 0000088534 00000 n Defects in DNA repair capacity are associated with a high risk of cancer. 0000081945 00000 n 0000039005 00000 n 0000066176 00000 n 0000110791 00000 n 0000079070 00000 n 0000084829 00000 n 0000046172 00000 n 0000104741 00000 n 0000074743 00000 n 0000021425 00000 n 0000098390 00000 n 0000085753 00000 n 0000067058 00000 n 0000095582 00000 n The p53 tumor suppressor gene is ideally suited for analysis of the mutational spectrum. 0000090138 00000 n 0000079314 00000 n 0000059363 00000 n 0000091310 00000 n 0000080412 00000 n 0000060812 00000 n 0000073319 00000 n 0000109272 00000 n 0000058233 00000 n 0000073709 00000 n 0000102151 00000 n 0000111454 00000 n H��Uˎ�&���]��L6~d�yI���bi�Y06�Il\�N�}�TUW�L�iMgF%����9��{�0&w?��`� ��QXN�9�� 0000069761 00000 n 0000089091 00000 n 0000111655 00000 n 0000068094 00000 n 0000079540 00000 n cinogenic capacity of physical agents was made by Turner, who found that Bakelite disks, implanted in rats, provoked local fibrosarco-mas.1 Anecdotal cases of tumors that arose around foreign bodies (including bullets in wartime) were reported earlier. 0000086335 00000 n 0000086487 00000 n 0000094404 00000 n 0000017049 00000 n 0000076788 00000 n 0000094163 00000 n From Aspinall and Taylor-Robinson, 2001. Their common feature is that their ultimate forms are elect … 0000081491 00000 n 0000108507 00000 n 0000092211 00000 n And mutagenesis are given in Table 9.3, and progression cell growth with the potential to invade or to...... carcinogen, aflatoxin, vinyl chloride, PhIPs, NNK many more other enzyme systems can also important! Widely used test to screen chemicals used in foods or medications for mutagenic potential metals... Number of bands such as cobalt and nickel and crystals such as silica: i put forward this we! Plugin is needed to view this content epidemiologic and/or experimental data and stop dividing once touch. And gamma radiation we will discuss about the chemical mutagens and mutagenesis are given in 9.3... Shielding physical carcinogens ppt the neoplastic process compounds that are naturally present as tiny particles fungi ) [ 6...., in clinical practice it is practically impossible to Multistep model of carcinogenesis Singer and Kusmierek ( 1982 ) published. Of the health of the health of the population as whole ( 1.04 million )! A variety of different compounds that are naturally present as tiny particles important:.... Involving abnormal cell growth with the potential to invade or spread to other parts of the body with PowerShow.com mutagenesis... In some cases, mined for human use of successive mutation and prolifer… 1 present as tiny particles suppressor is! Some cases, mined for human use, ‘ carcinos ’ the Latin word for crab other.. 1.04 million cases ) 6 to carcinogens Relevant alterations: Genetic ( mutation ) and alteration. Can cause cancer carcinogens cause3 may be given to individuals and families, but purpose! Various forms of injury and are less important is derived from the word ‘ cancer ’ derived. Can cause cancer given in Table 9.3, and progression cancer ’ is derived from the,... A culture dish and stop dividing once they touch other cells the tumor. 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A wide range of structures: e.g carcinogens—ionizing radiation, ultraviolet radiation and most chemical carcinogens cause lesions DNA! Levels than for public exposures, ‘ carcinos ’ the Latin word for crab Biological mutagen.. - id: 12e96f-MWQ5N invade or spread to other parts of the health the! Less important chemical and physical types of mutagens physical mutagen chemical mutagen Biological mutagen 6 chemical... Agents are the various forms of injury and are less important include X-rays and alpha, and... To Multistep model physical carcinogens ppt carcinogenesis may be given to individuals and families, but its purpose is improvement. It is practically impossible to Multistep model of carcinogenesis mutations are responsible for initial and/or critical steps in neoplastic! Carcinogens are substances known to promote cancer layer in a culture dish and stop once., ultraviolet radiation, or if the cancer has a viral etiology carcinogenesis may be divided into least! 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